Pharmacokinetics and Toxicology
| Code | School | Level | Credits | Semesters |
| PHAR4035 | Pharmacy | 4 | 20 | Spring UK |
- Code
- PHAR4035
- School
- Pharmacy
- Level
- 4
- Credits
- 20
- Semesters
- Spring UK
Summary
The pharmacokinetics (PK) of drugs is a crucial aspect of drug discovery and development, while an awareness of the potential for toxicological events is also essential in the pursuit of a successful medicine. This module provides an in-depth review of the principles of pharmacokinetics and toxicology in drug discovery and development from preclinical stages through to Investigational New Drug, clinical trials and launch.
The lectures and workshops material cover the following areas:
- Introduction to DMPK
- The influence of DMPK in drug discovery and development
- Principles of pharmacokinetics - ADMET'
- Prediction of human pharmacokinetics and dose
- Drug:drug interactions and PK in special populations
- In silico modelling of PK
- Adverse effects of drug exposure
Target Students
Students on MSc Drug Discovery orMSc Drug Discovery with Industrial Training (2 year)
Classes
Note that the following is an estimate only: 24 hours contact time, 20 hours directed learning, 156 hours self-directed study, revision and assessment. Total = 200 hours.
Assessment
- 50% Coursework 1: 2000 word essay.
- 50% Exam 1 (2-hour): Exam at the end of the semester.
Assessed by end of spring semester
Educational Aims
This module explores the role of pharmacokinetics in pre-clinical and clinical stages of the drug discovery and development process covering the in vivo administration of drugs and the key areas of absorption, distribution, metabolism, elimination and toxicity. In addition to the lecture course, students will engage in workshops designed to illustrate the principles of predictive modelling of drug disposition.Learning Outcomes
By the end of the module the student will be able to:
a) Demonstrate knowledge and understanding through ability to:
- CC1.1 - Critically evaluate and understand modern and historic approaches to drug discovery, demonstrating awareness of the future development of the subject.
- CC1.5 - critically evaluate the clinical development of medicines / devices.
- CC1.6 - critically evaluate the structure, regulation and organisation of key scientific disciplines within the pharmaceutical and health based industries (public / private).
b) Demonstrate an independent ability to:
- CC2.1 - Exercise the skills of critical reasoning in relation to the application of core scientific disciplines in the drug discovery process.
- CC2.3 - apply rigour in scientific and research method pertinent to drug discovery through independent study and a research project.
c) Demonstrate the ability to:
- CC3.2 - Organise and implement a programme of self-directed learning through reflective study.
Conveners
- Mrs Olusola Olafuyi
- Dr Stephen Paul Hilary Alexander